Research Papers in Peer Reviewed International Journals

        2014

  1. De Silva S, Tennekoon KH, Karunanayake EH, Amarasinghe I, Angunawela P, Analysis of BRCA1 and BRCA2 large genomic rearrangements in Sri Lankan familial breast cancer patients and at risk individuals. BMC Research Notes. 2014;7:344.
  2. Tennekoon KH, Poopalapillai J, Karunanayake AG, Jayasinghe HD, Kumarasiri JM, De S Wijesundera AP, Karunanayake EH, Association of Cord Blood Leptin, Soluble Leptin Receptor, Insulin-Like Growth Factor-I and Insulin-Like Growth Factor-Binding Protein-1 on Birth Indices in Healthy Full-Term Newborns. Hormone Research Paediatrics. 2014 (Epub ahead of print)
  3. Karlsson MF, Birgersson G, Witzgall P, Lekfeld JDS, Punyasiri PAN, Bengtsson M. Guatemalan potato moth Tecia solanivora distinguish odour profiles from qualitatively different potatoes Solanum tuberosum. Phytochemistry 85, 72-102
  4. Kottawa-Arachchi JD, Gunasekare MTK, Ranatunga MAB, Punyasiri PAN, Jayasinghe L, Karunagoda RP. Biochemical Characteristics of Tea (Camellia sinensis L.) Germplasm Accessions in Sri Lanka: Correlation between Black Tea Quality Parameters and Organoleptic Evaluation International Journal of Tea Science (in press)
  5. Rodrigo WW, Dassanayake RS, Karunanayake EH, Gunawardene YI, Weerasena OVDSJ, Heterologous expression, chaperone mediated solubilization and purification of parasitic nematode-specific growth factor-like protein of Setaria digitata. Asian Pacific journal of tropical medicine. 2014; 7(2): 85-92.
  6. Kumari KDKP, Weerakoon TCS, Handunnetti SM, Samarasinghe K, Suresh TS. Anti-inflammatory activity of dried flower extracts of Aegle marmelos in Wistar rats. Journal of Ethnopharmacology. 2014:151:1202-1208.
  7. Wickremasinghe R, Kumara R R, De Silva D E, Ratnasooriya W D, Handunnetti SM. Inhibition of phagocytic and intracellular killing activity of human neutrophils by aqueous and methanolic leaf extracts of Ixora coccinea.Journal of Ethnopharmacology. JEP-8720 (In Press.)
  8. Eugene EJ, Wickremesinghe SA, Kalugalage TL, Rodrigo C, Wickremesinghe H, Dikmadugoda N, Somaratne P, De Silva HJ, Rajapakse S, Handunnetti SM. Evaluation of two immunodiagnostic tests for early rapid diagnosis of leptospirosis in Sri Lanka: a preliminary study.Submitted to Transactions of Pathogens and Global Health. Manuscript submitted to Pathogens and Global Health. Ref No. PGH244.
  9. Jayasuriya WJABN, Fernando GH, Wanigatunga CA, Handunnetti SM. Abeytunga T, Suresh TS. Anti-inflammatory activity of Pleurotus ostreatus, a culinary medicinal mushroom, in Wistar rats.Manuscript submitted to Journal of the Science of Food and Agriculture. ID - JSFA-13-2193.
  10. Kothalawala SD, Edward D, Niloofa MJR, Premakumara GAS, Ratnasooriya WD, Handunnetti SM. Abeytunga T, Suresh TS. Immunomodulatory activity of combined hot water extract of Coriandrum sativum L and Coscinium fenestratum L in rats.Journal of Ethnopharmacology. manuscript number: JEP-D-14-00875.

  11.     2013

  12. Kalugalage TL, Rodrigo C, Vithanage T, Somaratne P, De Silva HJ, Handunnetti SM, Rajapakse S. Low serum total nitrite and nitrate levels in severe leptospirosis. BMC Infectious Diseases, 2013;13-206.
  13. Silva N, Senanayake H, Waduge V. Elevated levels of whole blood nickel in a group of Sri Lankan women with endometriosis: A case control study. BMC Research Notes. 2013; 6(1):13.
  14. Silva N, Tennekoon K, Senanayake H, Samarakoon S. Metalloestrogen cadmium stimulates proliferation of stromal cells derived from the eutopic endometrium of women with endometriosis. Taiwanese Journal of Obstetrics and Gynecology. 2013; 52(4): 540-545.
  15. Rodrigo WW, Dassanayake RS, Weerasena OVDSJ, Karunanayake EH, Heterologous expression of uncharacterized parasitic nematode-specific growth factor-like protein of Setaria digitata in Pichia pastoris expression systems.Tropical Biomedicine. 2013; 30 (2): 181–192.

  16.     2012

  17. Silva N, Senanayake H, Peiris-John R, Wickremasinghe R, Sathiakumar N, Waduge V. Presence of metalloestrogens in ectopic endometrial tissue. Journal of Applied Toxicology. 2012; ; 32(5):318-32.
  18. Silva N, Senanayake H, Peiris-John R, Wickremasinghe R, Senanayake H, Sathiakumar N. Presence of metalloestrogens in ectopic endometrial tissue. Journal of Pharmaceutical and Biomedical Sciences. 2012; ; 24 (24):1-5.
  19. Galhena BP, Samarakoon SR, Thabrew MI, Thammitiyagodage MG, Rathnasooriya WD, Tennekoon KH. Anti-inflammatory activity is a possible mechanism by which the polyherbal formulation comprised of Nigella sativa (seeds), Hemidesmus indicus (root), and Smilax glabra (rhizome) mediates its anti-hepatocarcinogenic effects. Evidence-Based Complementary and Alternative Medicine 2012; doi:10.1155/2012/108626.
  20. Gunaratna RI, Handunetti SM, Bulathsinghalage MRC, Somaratne P, Jayanaga A, De Silva HJ, Rajapakse S. Serum nitrite levels in Sri Lankan patients with leptospirosis. Asian Pacific Journal of Tropical Medicine 2012:75-78.
  21. Perera MK, Herath NP, Pathirana SL, Phone-Kyaw M, Alles HK, Mendis KN, Premawansa S, Handunnetti SM. Association of high plasma TNF-α levels and TNF-α/ IL-10 ratios with TNF2 allele in severe P. falciparum malaria patients in Sri Lanka. Pathogens & Global Health, Ref No PGH65 (In Press).
  22. Samarakoon SR, Thabrew I, Galhena PB, Tennekoon KH. Effects of a standardized preparation of a decoction comprised of Nigella sativa (seeds), Hemidesmus indicus (roots), and Smilax glabra (rhizome) on the expression of p53 and p21 genes in human hepatoma cells (HepG2) and livers of mice with chemically induced hepatocarcinogenesis. Tropical Journal of Pharmaceutical research 2012; 11 (1): 51-61.
  23. Samarakoon S, Thabrew I, Tennekoon K, Modulation of apoptosis in human hepatocellular carcinoma (HepG2 cells) by a standardized herbal decoction with anti- hepatocarcinogenic effects. BMC Complementary and Alternative Medicine- 2012, 12:25
  24. Tennekoon KH, Indika WL, Sugathadasa R, Karunanayake EH, Kumarasiri J, Wijesundera A. LEPR c.668A>G polymorphism in a cohort of Sri Lankan women with pre-eclampsia / pregnancy induced hypertension: a case control study. BMC Research Notes 2012; 5: 308
  25. Wijayalath W, Cheesman S, Tanabe K, Handunnetti S, Carter R, Pathiarana S. Strain-specific protective effect of the immunity induced by live malarial sporozoites under chloroquine cover. PLoS ONE, 2012: 7(9): e45861. doi:10.1371/journal.pone.0045861

  26.     2011

  27. Samarakoon SR, Thabrew I, Galhena PB, Tennekoon KH.  Effects of a standardized preparation of a decoction comprised of Nigella sativa (seeds), Hemidesmus indicus (roots), and Smilax glabra (rhizome) on the expression of p53 and p21 genes in human hepatoma cells (HepG2) and livers of mice with chemically induced hepatocarcinogenesis. Tropical Journal of Pharmaceutical research (In press).
  28. De Silva S, Tennekoon KH, Karunanayake EH, De Silva W, Amarasinghe I, Angunawela P (in press) Novel sequence variants and common recurrent polymorphisms of BRCA2 in Sri Lankan breast cancer patients and a family with BRCA1 mutations. Experimental and Therapeutic Medicine Published online on: Wednesday, August 17, 2011
  29. Jayanthiny P, Tennekoon KH, Karunanayake EH, Kumarasiri JM, Wijesundera APDeS. Di-nucleotide repeat polymorphisms of the insulin-like growth factor-I (IGF-I) gene and their association with IGF-I, insulin-like growth factor binding protein-1 and birth size in a Sri-Lankan cohort. Neonatology 2011; 100:37-43.
  30. Rajkumar G, Weerasena OVDSJ, Fernando KKS, Liyanage ASU and Rangika S. Genetic differentiation of Sri Lankan traditional rice (Oryza sativa) varieties and Wild rice species by AFLP markers. Nordic Journal of Botany. 2011; 29 (2): 238–243. doi: 10.1111/j.1756-1051.2011.00998.x
  31. Rajkumar G, Weerasena OVDSJ, Fernando KKS, Liyanage ASU. Assessment of Genetic Diversity among Sri Lankan Rice varieties by AFLP Markers. Plant Genetic Resources: Characterization and Utilization. 2011; 9:224-228. doi:10.1017/S1479262111000256

  32.     2010

  33. Sugathadasa BHKR, Tennekoon KH, Karunanayake EH, Kumarasiri JM Wijesundere APDeS. Association of -2548 G/A polymorphism in the leptin gene with preeclampsia/ pregnancy induced hypertension. Hypertension in Pregnancy. 2010; (doi:10.3109/10641950903214617).
  34. Samarakoon SR, Thabrew I, Galhena PB, De Silva D, Tennekoon KH. A comparison of the cytotoxic potential of standardized aqueous and ethanolic extracts of a polyherbal mixture comprised of Nigella sativa (seeds), Hemidesmus indicus (roots) and Smilax glabra (rhizome). Pharmacognosy Res. 2010; 26:335-342.
  35. Murugananthan A, Karunanayake EH, Tennekoon KH. Cloning and characterisation of alkali myosin light chain gene (MLC-3) of cattle filarial parasite Setaria digitata. IIAOB Journal. 2010 1; 1-10
  36. Rajkumar G , Weerasena OVDSJ , Fernando KKS , Liyanage ASU. AFLP Analysis of Genetic Relationships and Diversity of  Sri Lankan Oryza sativa cultivars (Improved Varieties). Journal of Biotechnology. 2010; 150S:539. doi:10.1016/j.jbiotech.2010.09.886

  37.     2009

  38. Dassanayake RS, Rodrigo WWR, Karunanayak EH, Weerasena OVDSJ, Chandrasekharan NV. A putative nuclear growth factor-like globular nematode specific proteinBioinformation. 2009; 3:370-374
  39. Handunnetti SM, Kumara RR, Nanayakkara AA, Deraniyagala SA, Ratnasooriya WD. Anti-inflammatory activity of methanolic leaf extract of Ixora coccinea.  Pharmacognosy Research. 2009; 1:80-90.

  40.     2008

  41. De Silva W, Karunanayake EH, Tennekoon KH, Allen M, Amarasinghe I, Angunawala P, Ziard MH.
    Novel sequence variants and a high frequency of recurrent polymorphisms in BRCA 1 gene in Sri Lankan breast cancer patients and at risk individuals. BMC Cancer. 2008; 8:214.

  42.     2007

  43. Ariyaratne HACK, Everad JMDT, Karunanayake EH. Diseased sugarcane in Sri Lanka is infected with sugarcane grassy shoot and /or sugarcane white leaf phytoplasma. Australasian Plant Diseases Notes. 2007; 2: 123-125.
  44. Tennekoon KH, Eswaramohan, T, Karunanayake EH. Effect of leptin on prolactin and insulin-like growth factor-I secretion by cultured rat endometrial stromal cells. Fertility and Sterility. 2007; 88: 193-199