Research Publications

  1. Mevan KM, Everard JMTD, Liyanage AC, Gunasekera MTK, Tirimanne TLS, Karunanayake EH. Studying genetic relationships among Tea cultivars in Sri Lanka using RAPD markers. Journal of Tea Science, 2004; 70 (1), 42-53

 

  1. Silva WPK, Deraniyagala SA, Wijesundera R, Karunanayake E, Priyanka US. Isolation of scopoletin from leaves of Hevea brasiliensis and the effect of scopoletin on pathogens of brasiliensis. Mycopathologia, 2004; 153:199-202.

 

  1. Weerasena, J.S., Steffenson, B.J. & Falk, A.B. Conversion of an amplified fragment length polymorphism marker into a co-dominant marker in the mapping of theRph15 gene conferring resistance to barley leaf rust, Puccinia hordeiTheor Appl Genet, 2004; 108, 712–719. https://doi.org/10.1007/s00122-003-1470-2.

 

  1. Weerasena OJ, Chandrasekharan NV, Wijesundera RLC. Development of a DNA probe and a PCR based diagnostic assay for Rhizoctonia solaniusing a repetitive DNA sequence cloned from a Sri Lankan isolate. Mycological Research, 2004; 108 (6), 649-653.

 

  1. Pathirana SL, Alles HA, Sumith Bandara, Myat Phone-Kyaw, Perera MK, Wickremesinghe AR, Mendis KN and Handunnetti SM. ABO blood group types and protection against severe Plasmodium falciparum Annals of Tropical Medicine & Parasitology, 2005; 99: 119-124.

 

  1. Tennekoon K H, Wasalathanthri S, Jeevathayaparan S, Karunanayake E H. Serum leptin and  lactational amenorrhoea in well-nourished and undernourished lactating women. Fertility and Sterility, 200583: 988-994
  1. Merino EF, Fernandez-Becerra C, Alan C, Durham M, Ferreira JE, Tumilsci VF, d’Arc-Neves J, da Silva-Nunes M, Ferreira MU, Wickramarachchi TA, Udagama-Randeniya PV, Handunnetti SM and del Portillo HA. Multi-character population study of the vir subtelomeric multigene superfamily of Plasmodium vivax, a major human malaria parasite. Molecular Biochemical Parasitology, 2006; 149: 10-16.

 

  1. Wickramarachchi T, Premaratne PH, Perera KLRL, Bandara S, Kocken CHM, Thomas AW, HandunnettiSM and Udagama-Randeniya PV. Natural human antibody responses to Plasmodium vivax apical membrane antigen 1 under low transmission and unstable malaria conditions in Sri Lanka. Infection & Immunity, 2006; 74:798-801.

 

  1. Munasinghe-Gunasekera A, Wickramarachchi WTA, Ganguli I, Perera KLRL, Premaratne H, Handunnetti SM, Udagama-Randeniya PV and Wirth DF. Genetic diversity and selection at the Plasmodium vivax apical membrane antigen-1 (PvAMA-1) locus in a Sri Lankan population. Molecular Biology & Evolution, 2007; 24:939-942.

 

  1. Pathmaperuma AN, Tennekoon KH, Senanayake L, Karunanayake EH. Maternal and cord blood levels of insulin-like growth factors –I and -II and insulin-like growth factor binding protein-1: correlation with neonatal and maternal anthropometric indices. Ceylon Medical Journal, 2007; 52: 48-52

 

  1. Tanabe K, Escalante A, Sakihama N, Honda M, Arisue N, Horii T, Culleton R, Hayakawa T, Hashimoto Tetsuo, Longacre S, Pathirana S, Handunnetti S, Kishino H. Recent independent evolution of msp1 polymorphism in Plasmodium vivax and related simian malaria parasites. Molecular Biochemical Parasitology, 2007; 156:74-79.

 

  1. Tennekoon K H, Eswaramohan, T, Karunanayake EH. Effect of leptin on prolactin and insulin-like growth factor-I secretion by cultured rat endometrial stromal cells. Fertility and Sterility, 2007;88: 193-199.

 

  1. Tennekoon KH, Pathmaperuma AN, Senanayake L, Karunanayake EH. Insulin-like growth factors -I and -II and Insulin-like growth factor binding protein-1 during normal pregnancy in women: correlation with other placental hormones. Ceylon Medical Journal, 2007; 52: 8-13.

 

  1. Wickramarachchi WTA, Illeperuma RJ, Perera KLRL, Bandara S, Longacre S, Handunnetti SM and Udagama-Randeniya PV. Comparison of naturally acquired antibody responses against the C-terminal products of Plasmodium vivax merozoite surface protein-1 under low transmission and unstable malaria conditions in Sri Lanka. International Journal of Parasitology, 2007; 37: 199-208.
  1. De Silva W, Karunanayake EH, Tennekoon KH, Allen M, Amarasinghe I, Angunawala P, Ziard MH. Novel sequence variants and a high frequency of recurrent polymorphisms in BRCA 1 gene in Sri Lankan breast cancer patients and at risk individuals. BMC Cancer, 2008; Jul 29; 8: 214.

 

  1. Niroshini E, Everard J, Karunanayake E, Tirimanne TLS. Detection of sequence characterized amplified region (SCAR) markers linked to sex expression in Carica papaya Journal of The National Science Foundation of Sri Lanka, 2008; 36:145.

 

  1. Silva NY, Tennekoon KH, Senanayake L, Karunanayake EH. Cord blood leptin levels in normal pregnancy, pregnancy induced hypertension and gestational diabetes mellitus. Ceylon Medical Journal, 2008; Sep; 53(3):79-82.

 

  1. Wijayalath W, Cheesman S, Rajakaruna J, Handunnetti S, Carter R, Pathirana S. Evidence for strain-specific protective immunity against blood-stage parasites of Plasmodium cynomolgi in toque monkey. Parasite Immunology. 2008; 30: 630-636.

 

  1. SR Weerakoon, O Weerasena, PKD Peiris, S Somaratne. Differentiation of Sri Lankan mustard (Brassica juncea) accessions using FAFLP markers and Agro-Morphological data. Research Journal of Biotechnology, 2008; 239-243.
  1. Dassanayake RS, Rodrigo WWR, Karunanayak EH, Weerasena OVDSJ, Chandrasekharan NV. A putative nuclear growth factor-like globular nematode specific protein. Bioinformation. 2009; 3(9):370-374.

 

  1. Munasighe RA, Ileperuma M, Kapilananda GM, Premawansa G, Handunnetti SM, Premawansa S. Spleen modulation of cytoadherence properties of Plasmodium falciparum. Scandinavian Journal of Infectious Diseases. 2009; 41:538-539.

 

  1. Handunnetti SM, Kumara RR, Nanayakkara AA, Deraniyagala SA, Ratnasooriya WD. Anti-inflammatory activity of methanol leaf extract of Ixora coccinea. Pharmacognosy Research. 2009; 1:80-90.
  1. Arawwawala M, Thabrew I, Arambewela L, Handunnetti S. Anti-inflammatory activity of Trichosanthes cucumerina in rats. Journal of Ethnopharmacology. 2010; 131:538-543.

 

  1. Gomes TS, Lindner U, Tennekoon KH, Karandagoda W, Gortner L, Obeid R. Homocysteine in small for gestational age and appropriate for gestational age preterm neonates from mothers receiving folic acid supplementation. Clinical Chemistry and Laboratory Medicine. 2010; 48:1157-1161.

 

  1. Murugananthan A, Karunanayake EH, Tennekoon KH. Cloning and characterisation of alkali myosin light chain gene (MLC-3) of cattle filarial parasite Setaria digitata. IIAOB Journal. 2010; 1(4). https://www.researchgate.net/publication/47740988

 

  1. Pathirana PPSL, Ekanayake K, Howard RJ, Mendis KN, and Handunnetti SM. Expression of surface antigens, cytoadherence and their association with clinical symptoms in acute Plasmodium falciparum infections from Sri Lanka. The Journal of National Science Foundation. 2010; 38:233-240.

 

  1. Samarakoon SSR, Thabrew I, Galhena PB, De Silva D, Tennekoon KH. A Comparison of the Cytotoxic Potential of Standardized Aqueous and Ethanolic Extracts of a Polyherbal Mixture Comprised of Nigella sativa (seeds), Hemidesmus indicus (roots) and Smilax glabra (rhizome). Pharmaconosy Research. 2010;6 215-222.

 

  1. Sawai H, Sawai H, Otani H, Arisue N, Palacpac N, de O Martins L, Pathirana S, Handunnetti S, Kawai S, Kishino H, Horii T and Tanabe K. Lineage-specific positive selection at the merozoite surface protein 1 (msp1) locus of Plasmodium vivax and related simian malaria parasites. BMC Evolutionary Biology. 2010; 10: 52.

 

  1. Sugathadasa BHKR, Tennekoon KH, Karunanayake EH, Kumarasiri JM Wijesundere APDeS. Association of -2548 G/A polymorphism in the leptin gene with preeclampsia/ pregnancy induced hypertension. Hypertension in Pregnancy. 2010; 29:366-374.

 

  1. Weerakoon SR, Weerasena OVDSJ, Peiris PKD, Somaratne S. Differentiation of Sri Lankan mustard (Brassica juncea) accessions using FALFP markers and Agro-Morphological data. Research Journal of Bio Technology. (In press).

 

  1. Wickramarachchi T, Premaratne PH, Dias S, Handunnetti SM and Udagama-Randeniya PV. Genetic complexity of Plasmodium vivax infections in Sri Lanka reflected at the Merozoite Surface Protein-3α locus Annals of Tropical Medicine and Parasitology 2010; 104:95-108.
  1. Ariyarathna HCK, Everard J, Karunanayake E. Diseased sugarcane in Sri Lanka is infected with sugarcane grassy shoot and/or sugarcane white leaf phytoplasma. Australasian Plant Disease Notes. 2011; 2:123-125.

 

  1. De Silva S, Tennekoon KH, Karunanayake EH, De Silva W, Amarasinghe I, Angunawela P (in press). Novel sequence variants and common recurrent polymorphisms of BRCA2 in Sri Lankan breast cancer patients and a family with BRCA1 Experimental and Therapeutic Medicine. Published online on: Wednesday, August 17, 2011.

 

  1. Jayanthiny P, Tennekoon KH, Karunanayake EH, Kumarasiri JM, Wijesundera APDeS. Di-nucleotide repeat polymorphisms of the insulin-like growth factor-I (IGF-I) gene and their association with IGF-I, insulin-like growth factor binding protein-1 and birth size in a Sri-Lankan cohort. Neonatology 2011; 100:37-43.

 

  1. Rajkumar G, Weerasena OVDSJ, Fernando KKS, Liyanage ASU and Rangika S. Genetic differentiation of Sri Lankan traditional rice (Oryza sativa) varieties and Wild rice species by AFLP markers. Nordic Journal of Botany. 2011; 29 (2): 238–243.

 

  1. Rajkumar G, Weerasena OVDSJ, Fernando KKS, Liyanage ASU. Assessment of Genetic Diversity among Sri Lankan Rice varieties by AFLP Markers. Plant Genetic Resources: Characterization and Utilization. 2011; 9:224-228.
  1. Amarasekara DS, Wijerathna S, Fernando C, Udagama PV. Cost- effective diagnosis of male oxidative stress using the nitroble tetrazolium test: useful application for the developing world. Andrologia. 2012 Nov 16. Doi: 10.1111/and.12043.

 

  1. Galhena BP, Samarakoon SR, Thabrew MI, Thammitiyagodage MG, Rathnasooriya WD, Tennekoon KH. Anti-inflammatory activity is a possible mechanism by which the polyherbal formulation comprised of Nigella sativa (seeds), Hemidesmus indicus (roots), and Smilax glabra (rhizome) mediates its anti-hepatocarcinogenic effects. Evidence – Based Complementary and Alternative Medicine. 2012; doi;10.1155/2012/108626.

 

  1. Gunaratna RI, Handunnetti SM, Bulathsinghala MRC, Somarathne P, Jayanaga A, De Silva HJ, Rajapakse S. Serum nitrate levels in Sri Lankan patients with leptospirosis. Asian Pacific Journal of Tropical Medicine. 2012: 75-78.

 

  1. Samarakoon SR, Thabrew I, Galhena PB, Tennekoon KH. Effects of a standardized preparation of a decoction comprised of Nigella sativa (seeds), Hemidesmus indicus (roots), and Smilax glabra (rhizome) on the expression of p53 and p21 genes in human hepatoma cells (HepG2) and livers of mice with chemically induced hepatocarcinogenesis. Tropical Journal of Pharmaceutical research. 2012; 11 (1): 51-61.

 

  1. Samarakoon S, Thabrew I, Tennekoon K. Modulation of apoptosis in human hepatocellular carcinoma (HepG2) by a standardized herbal decoction with anti-hepatocarcinogenic effects. BMC Complementary and Alternative Medicine-2012, 12:25.

 

  1. Tennekoon KH, Indika WL, Sugathadasa R, Karananayake EH, Kumarasiri J, Wijesundara A. LEPR c.668>G polymorphism in a cohort of Sri Lankan women with pre-eclampsia/ pregnancy induced hypertention: a case control study. BMC Research Notes. 2012; 5: 308.

 

  1. Wijayalath W, Cheeseman S, Tanabe K, Handunnetti S, Carter R, Pathirana S. Strain- specific protective effect of the immunity induced by live malarial sporozoites under chloroquine cover. PLoS ONE, 2012: 7(9): e45861. doi:10.1371/journal.pone.0045861.

 

  1. Arawwawela LDAM, Thabrew MI, Arambewela LSR. Trichosanthes cucumerina Linn: Investigations of some selected pharmacological activities of ethanolic    DOI: 10.5567 / Pharmacologia, 2013, 493 – 497.

 

  1. Kalugalage TL, Rodrigo C, Vithanage T, Somaratne P, De Silva HJ, Handunnetti SM, Rajapakse S. Low serum total nitrite and nitrate levels in severe leptospirosis. BMC Infectious Diseases, 2013; 13-206.

 

  1. Karlsson MF, Birgersson G, Witzgall P, Lekfeld JDS, Punyasiri PAN, Bengtsson M. Guatemalan potato moth Teciasolanivora distinguish odour profiles from qualitatively different potatoes Solanum tuberosum, Phytochemistry, 2013; 85, 72-102.

 

  1. Kottawa-Arachchi JD, Gunasekare MTK, Ranatunga MAB, Punyasiri PAN, Jayasinghe L. Use of biochemical compounds in tea germplasm characterization and its implications in tea breeding in Sri Lanka. The Journal of National Science Foundation Sri Lanka, 2013; 41:309-318.

 

  1. Perera MK, Herath NP, Pathirana SL, Phone-Kyaw M, Alles HK, Mendis KN, Premawansa S, Handunnetti SM. Association of high plasma TNF-α levels and TNF-α/ IL-10 ratios with TNF2 allele in severe Plasmodium falciparum malaria patients in Sri Lanka. Pathogens & Global Health, 2013; 107:21-29.

 

  1. Rodrigo WW, Dassanayake RS, Weerasena SJ, Karunanayake EH. Heterologous expression of uncharacterized parasitic nematode-specific growth factor-like protein of Setaria digitata in Pichia pastoris expression systems. Tropical Biomedicine, 2013; 30 (2): 181–192.

 

  1. Sanmugarajah V, Thabrew I, Sivapalan S.R. A Quality Assessment {Phyto, Physicochemical Profile} of Root of Withania somnifera (Linn) Dunal. International Journal of Advances in Science and Technology, 2013; 7, (1), PP. 64 – 72.

 

  1. Sanmugarajah V, Thabrew I, Sivapalan, S.R. Phyto-physicochemical standardization of medicinal plant Enicostemma littorale IOSR Journal of Pharmacy, 2013; 3 (2), 52 – 58.

 

  1. Sanmugarajah V, Thabrew I, Sivapalan, S.R. Preliminary phytochemical screening of different plant extracts of whole plant of Enicostemma littorale International Journal of Sciences: Basic and Applied Research (IJSBAR). 2013; 11(1): 99-104.

 

  1. Silva N, Senanayake H, Waduge V. Elevated levels of whole blood nickel in a group of Sri Lankan women with endometriosis: A case control study. BMC Research Notes. 2013; 6(1):13.

 

  1. Silva N, Tennekoon K, Senanayake H, Samarakoon S. Metalloestrogen cadmium stimulates proliferation of stromal cells derived from the eutopic endometrium of women with endometriosis. Taiwanese Journal of Obstetrics and Gynecology. 2013; 52(4): 540-545.

 

  1. Carvalho E, Punyasiri PAN, Somasiri HPPS, Abeysinghe ISB, Martens S. Quantification of γ-aminobutyric acid in Sri Lankan tea by means of ultra performance tandem mass spectrometry.Natural Products Communications. 2014; 9(4),525-528/

 

  1. De Silva S, Tennekoon KH, Karunanayake EH, Amarasinghe I, Angunawela P, Analysis of BRCA1 and BRCA2 large genomic rearrangements in Sri Lankan familial breast cancer patients and at risk individuals.BMC Research Notes. 2014;7:344.

 

  1. De Silva NL, Niloofa MJR, Fernando TRGN, Karunanayake L, Rodrigo C, de Silva HJ, Premawansa S, Handunnetti SM,Rajapaksa S. Changes in full blood count parameters leptospirosis: A prospective study. International Archives of Medicine, 2014, 7:31 doi:10.1186/1755-7682-7-31.

 

  1. Dissanayake S, Kottearchchi NS, Weerasena J, Peiris M. Development of a CAPS marker for the badh2.7 allele in Sri Lankan fragrant rice (Oryza sativa) Plant Breeding: 2014: 133(5): 560-565.

 

  1. Ediriweera SS, Wijesundera RLC, Nanayakkara CM and Weerasena OVDSJ. A new record of Fulvifomes fastuosus from Sri Lanka. The Journal National Science Foundation Sri Lanka: 2014: 42 (4):369-371

 

  1. Ediriweera SS, Wijesundera RLC, Nanayakkara CM, Weerasena OVDSJ. Macrofungi from the Sigiriya wilderness in Sri Lanka. Journal of Mycopathological Research: 2014: 52(1):47-51. 7.

 

  1. Hewage AS, Jayanthiny P, Tennekoon KH, Kumarasiri JM, Wijesundere, Karunanayake EH. H19 rs217727 genotype and IGF-1/intron -2 dinucleotide CT repeat polymorphism are independently associated with birth weight. 2014; DOI 10.1007/s12020-014-0402/

 

  1. Karlsson MF, Birgersson G, Witzgall P, Lekfeld JDS, Punyasiri PAN, Bengtsson M. Guatemalan potato moth Tecia solanivoradistinguish odour profiles from qualitatively different potatoes Solanum tuberosum. Phytochemistry, 2014 85, 72-102.

 

  1. Kumari KDKP, Weerakoon TCS, Handunnetti SM, Samarasinghe K, Suresh TS. Anti-inflammatory activity of dried flower extracts of Aegle marmelos in Wistar rats.Journal of Ethnopharmacology. 2014:151:1202-1208

 

  1. Nagaratnam N, Karunanayake EH, Tennekoon KH, Samarakoon SR, Mayan K. In silico characterization of a RNA binding protein of cattle filarial parasite Setaria digitata.Bioinformation. 2014.10(8): 521-516.

 

  1. Rodrigo WW, Dassanayakea RS, Karunanayake EH, Silva YIN, Weerasena OVDSJ. Heterologous expression, chaperone mediated solubilization and purification of parasitic nematodespecific growth factor like protein of Setaria digitata. Asian Pacific Journal of Tropical Medicine. 2014: 7:85-92 18

 

  1. Samarakoon SR, Kotigala S, Liyanage IG, Thabrew I, Tennekoon KH, Siriwardane A and Galhena PB. Cytotoxic and apoptotic effects of a decoction of aerial parts of Flueggea leucopyrus on human endometrial carcinoma (AN3CA) cells. Tropical Journal of Pharmaceutical Research, 2014, 13: 873-880.

 

  1. Sanmugarajah V, Thabrew I, Sivapalan, SR Standardization of Vellarugu choornam, A Siddha herbal drug.  International Journal of Ayurveda and Pharma Research, 2014; 2:44-53.

 

  1. Vinotha S, Thabrew I, Sri Ranjani S. In vitro antioxidant activity of two selected herbal medicines. International Science Index. 2014; 8:35-40.

 

  1. Wickremasinghe R, Kumara R R, De Silva D E, Ratnasooriya W D, Handunnetti S M. Inhibition of phagocytic and intracellular killing activity of human neutrophils by aqueous and methanolic leaf extracts of Ixora coccinea. Journal of Ethnopharmacology, 2014;153: 900–907.
  1. Amarasinghe APPR, Siriwardhane DAS, Samarasekera RR, Weerasena OVDSJ. Development of DNA barcodes and optimization of DNA isolation and PCR protocols for a medicinal plant Plectranthus hadiensis. International Journal of Science and Research. 2015; 4(6) 2852-2856.

 

  1. Ediriweera SS, Wijesundera RLC, Nanayakkara CM,Weerasena OVDSJ.Comparative study of growth and yield of edible mushrooms, Schizophyllumcommune , Auricularia polytricha (Mont.) Sacc. and Lentinus squarrosulus Mont.on lignocellulosic substrates. Mycosphere. 2015; 6 (6): 760–765.

 

  1. Ediriweera S, Wijesundera R, Nanayakkara C, Weerasena J. First report of Panaeolus sphinctrinus and Panaeolus foenisecii (Psathyrellaceae, Agaricales) on elephant dung from Sri Lanka, Frontiers in Environmental Microbiology. 2015; 1(2): 19-23.

 

  1. Eugene EJ, Handunnetti SM, Wickramasinghe SA, Kalugalage TL, Rodrigo C, Wickramasinghe H, Dikmadugoda N, Somaratne P, de Silva HJ and Rajapakse S. Evaluation of two immunodiagnostic tests for early rapid diagnosis of leptospirosis in Sri Lanka: a preliminary study. BMC Infectious Diseases. 2015;15:319 DOI 10.1186/s12879-015-1080-z.

 

  1. Rajkumar G, Weerasena OVDSJ, Fernando KKS. A study of genetic diversity in Oryza rhizomatis A. Vaughan accessions using AFLP markers and morphological traits. Tropical Plant Research. 2015; 2(1): 10-16.

 

  1. Hewage AS, Jayanthiny P, Tennekoon KH, Kumarasiri JM, De S Wijesundere AP, Karunanayake EH. H19 rs217727 genotype and IGF-1/intron -2 dinucleotide CTrepeat polymorphism are independently associated with birth weight. 2015; 48(3):1010-2. doi: 10.1007/s12020-014-0402-z

 

  1. Karunarathna KDK, Weerakoon SR, Somaratne S, Weeresena OVDSJ. Molecularand agro-morphological differences among traditional rice variety “Pachchaperumal” and closely related weedy rice eco-types in Sri Lanka. International Journal of Tropical Agriculture. 2015; 33.

 

  1. Mendis AS., Thabrew I, Samarakoon, SR, Tennekoon, KH. (2015) Modulation of expression of heat shock proteins and apoptosis by Flueggea leucopyrus (Willd) decoction in three breast cancer phenotypes. BMC Complementary and Alternative Medicine, 15:404. DOI: 10.1186/s12906-015-0927-6

 

  1. Niloofa R, Fernando N, de Silva NL, Karunanayake L, Wickramasinghe H,Dikmadugoda N, Premawansa G, Wickramasinghe R, de Silva HJ, Premawansa S, Rajapakse S, Handunnetti S. Diagnosis of Leptospirosis: Comparison between Microscopic Agglutination Test, IgM-ELISA and IgM Rapid Immunochromatography Test. PLoS ONE. 2015 Jun 18; 10(6): e0129236. doi:10.1371/ journal.pone.0129236.

 

  1. Piyathilaka MAPC, Pathmalal MM, Tennekoon KH, Samarakoon SR, Chanthirika S, and de Silva BGDNK. 2015. Microcystin LR induced cytotoxicity and apoptosis on human embryonic kidney (HEK 293) and human kidney adenocarcinoma (ACHN) cell lines. Microbiology, 161 (Pt 4), 819-828.

 

  1. Rajapakse S, Rodrigo C, Handunnetti SM, Fernando SD. Current immunological and molecular tools for leptospirosis: diagnostics, vaccine design, and biomarkers for predicting severity. Annals of Clinical Microbiology and Antimicrobials. 2015 Jan 16;14:2. doi: 10.1186/s12941-014-0060-2DOI 10.1186/s12941-014-0060-2.

 

  1. Rajapakse Senaka, Praveen Weeratunga, M.J. Roshan Niloofa, Narmada Fernando, Chathuraka Rodrigo, Sachith Maduranga, Nipun Lakshitha Fernando, H. Janaka De Silva, Lilani Karunanayake, Shiroma Handunnetti. Clinical and laboratory associations of severity in a Sri Lankan cohort of patients with serologically confirmed leptospirosis – A prospective study. Transactions of Royal Society of Tropical Medicine Hygiene. 2015;109 (11): 710-716.

 

  1. Ranasinghe R, Tennekoon KH, Karunanayake EH, Lembring M, Allen M. 2015 Astudy of genetic polymorphisms in mitochondrial DNA hypervariable regions I and II of the five major ethnic groups and Vedda population in Sri Lanka. Legal Medicine (Tokyo). 2015; 17: 539-546.

 

  1. Ratnasooriya WD, Jayakody J, Handunnetti SM, Ratnasooriya C, Weerasekera KR. Anti-nflammatory activity of hot water infusion of Nyctanthes arbortristis Indian Journal of Pharmacological Science. 2015:77:613-9.

 

  1. Sathkumara H, De Silva AD, De Silva NR, Handunnetti S. Common variable immunodeficiency and role of transmembrane activator and calcium-modulator and cyclophilin ligand interactor. International Journal of Immunogenetics. 2015 (19 JUN), DOI: 10.1111/iji.12217.

 

  1. Vinotha S., Thabrew I, Sri Ranjani S. Phytochemical screening of various extracts of Root of Withania somnifera (L) Dunal. Archives of Business Research, 2015; 3:179-184.

 

  1. Vinotha S, Thabrew I, Sri Ranjani S. Standardization of Amukkirai chooranam, a Traditional Herbal Preparation in Siddha System of medicine. European Journal of Medicinal Plants. 2015; 5(2): 1-13. Article EJMP 2015 013

 

  1. Wickramasinghe LJM, Bandara IN, Vidanapathirana DR, Tennekoon KH, Samarakoon SR, Wickramasinghe N. Pseudophilautus dilmah, a new species of shrub frog (Amphibia: Anura: Rhacophoridae) from a threatened habitat Loolkandura in Sri Lanka. Journal of Threatened Taxa. 2015; 7(5): 7089-110.
  1. de Silva KS, Tennekoon KH, Sundralingam T, Navarathne B, Hewage AS, de Silva WS, Ganihigama D, Jayasinghe HD, Muhandiram ME. Growth hormone releasing hormone receptor codon 72 mutation in a cohort of Sri Lankan patients with growth hormone deficiency. Ceylon Medical Journal, 2016 Mar; 61(1):18-21

 

  1. De Silva, S, Tennekoon, KH, Dissanayake, A, De Silva K, Jayasekera L. Novel and reported pathogenic variants in exon 11 of BRCA2 gene in a cohort of Sri Lankan young breast cancer patients. Familial Cancer. 2016 December 30. Doi:10.1007/s10689-016-9962-9

 

  1. Ediriweera MK, Tennekoon KH, Adhikari A, Samarakoon SR, Thabrew I, de Silva ED. New halogenated constituents from Mangifera zeylanica Hook.f. and their potential anti-cancer effects in breast and ovarian cancer cells. Journal of Ethnopharmacology. 2016 May 17. pii: S0378-8741(16)30314-2. doi: 10.1016/j.jep.2016.05.047. [Epub ahead of print].

 

  1. Ediriweera PMK, Tennekoon KH, Samarakoon SR, Thabrew I, de Silva ED. Induction of apoptosis in MCF-7 breast cancer cells by Sri Lankan endemic mango (Mangifera zeylanica) fruit peel through oxidative stress and analysis of its phytochemical cayonstituents. Journal of Food Biochemistry, 28 May 2016 DOI: 10.1111/jfbc.12294

 

  1. Ediriweera PMK, Tennekoon KH, Samarakoon SR, Thabrew I, de Silva ED. Cytotoxic and apoptotic effects of the bark of two common mango (Mangifera indica) varieties from Sri Lanka on breast and ovarian cancer cells. British Journal of Pharmaceutical Research, 2016; DOI: 10.9734/BJPR/2016/24004

 

  1. Ediriweera PMK, Tennekoon KH, Samarakoon SR, Thabrew I, de Silva ED. A study on potential anticancer activity of Mangifera zeylanica bark: Evaluation of the cytotoxic and apoptotic effects of the hexane extract and bioassay guided fractionation to identify phytochemical constituents. Oncology Letters, 2016; 11: 1335-1344

 

  1. Fernando N, Shalini Wickramasinghe, Roshan Niloofa, Chathuraka Rodrigo, Lilani Karunanayake, H Janaka de Silva, Rajitha Wickramasinghe, Sunil Premawansa, Senaka Rajapakse, Shiroma Handunnetti. Protein carbonyl as a biomarker of oxidative stress in severe leptospirosis, and its usefulness in differentiating leptospirosis from dengue infections. PLoS ONE. 2016; 11(6): e0156085. doi:10.1371/journal. pone.0156085

 

  1. Fernando VAK, Jagath Weerasena, Inoka C. Perera, Chandima D. Dangalle, Shiroma Handunnetti, Sunil Premawansa , Mayuri R. Wijesinghe. Hexavalent chromium induced lethal and sub-lethal effects in the Asian common toad Duttaphrynus melanostictus. Aquatic Toxicology, 2016; 177:98-105. May 2016, DOI:10.1016/j.

 

  1. Jayarathna PP, Tennekoon KH, Samarakoon SR, Thabrew I, Karunanayake EH, de Silva ED, Ediriweera MK. Cytotoxic, Antioxidant and Apoptotic Effects of Twenty Sri Lankan Endemic Plants in Breast Cancer Cells. European Journal of Medicinal Plants, 2016, 15(1) DOI: 10.9734/EJMP/2016/26591

 

  1. Kumari KDKP, Samarasinghe K, Handunnetti SM, Suresh TS. Preliminary Studies on Activity Guided Fractionation of the Ethanolic Extract of Dried Flowers of Aegle Marmelos. International Journal of Green and Herbal Chemistry. 2016; 5(2): 122-138.

 

  1. Rajapakse S, Praveen Weeratunga, M.J. Roshan Niloofa, Narmada Fernando, Nipun Lakshitha Fernando, Chathuraka Rodrigo, Sachith Maduranga, Nuwanthi Nandasiri, Sunil Premawansa, H. Janaka De Silva, Lilani Karunanayake, Shiroma Handunnetti. A diagnostic scoring model for leptospirosis in resource limited settings- A prospective study. PLOS Neglected Tropical Diseases. 2016; 10 (6): e0004513. doi:10.1371/journal.pntd. 0004513

 

  1. Samaradivakara SP, Radhika Samarasekera, Shiroma M Handunnetti, Jagathpriya Weerasena. Cholinesterase, protease inhibitory and antioxidant capacities of Sri Lankan medicinal plants. Industrial Crops & Products, 2016; 83:227-234.

 

  1. Samarakoon SR, Fernando N, Ediriweera MK, Adhikari A, Wijayabandara L, de Silva ED, Tennekoon KH. Isolation of Hopenone-I from the Leaves of Mangrove Plant Scyphiphora hydrophyllacea and Its Cytotoxic Properties. British Journal of Pharmaceutical Research, 2016, 10(1); DOI : 10.9734/BJPR/2016/23317

 

  1. Samarakoon SR, Shanmuganathan C, Ediriweera MK, Piyathilaka P, Tennekoon KH, Thabrew I. Screening of Fifteen Mangrove Plants Found in Sri Lanka for in-vitro Cytotoxic Properties on Breast (MCF-7) and Hepatocellular Carcinoma (HepG2) Cells. European Journal of Medicinal Plants, 2016, 14(4) DOI: 10.9734/EJMP/2016/26107

 

  1. Senathilake KS, Karunanayake EH, Samarakoon SR, Tennekoon KH, de Silva ED. Rhizome extracts of Curcuma zedoaria Rosc induce caspase dependant apoptosis via generation of reactive oxygen species in filarial parasite Setaria digitata in vitro. Experimental Parasitology, 2016 May 10;167:50-60. doi: 10.1016/j.[Epub ahead of print].

 

  1. Wickremesinghe R, Shiroma Handunnetti. Role of Human Neutrophils in Inflammation and it’s Modulation by Ixora coccinea. Research and Reviews: A Journal of Immunology, 2016; 6(1):32-48.
  1. Ediriweera MK, Tennekoon KH, Samarakoon SR, Adhikari A, Thabrew I, Dilip de Silva E. Isolation of a new resorcinolic lipid from Mangifera zeylanicaf. bark and its cytotoxic and apoptotic potential. Biomed Pharmacother. 89:194-200. doi: 10.1016/j.biopha.2017.01.176. [Epub ahead of print].

 

  1. Ediriweera MK, Tennekoon KH, Samarakoon SR, Thabrew I, de Silva ED. Protective Effects of Six Selected Dietary Compounds against Leptin-Induced Proliferation of Oestrogen Receptor Positive (MCF-7) Breast Cancer Cells. Medicines (Basel). 2017 Jul 26;4 (3). pii: E56. doi: 10.3390/medicines4030056.

 

  1. Ekanayaka EMSI, SR Weerakoon, S Somaratne, OVDSJ Weerasena. Developing herbicide resistant Sri Lankan rice (Oryza sativa) varieties: An application of Self Organizing Map. Information Processing in Agriculture, 2017: 4(2); 140-149.

 

  1. Jayathilaka DK, Tennekoon KH, de Silva KSH, De Silva S. A pilot study on CYP21 gene deletions among a cohort of Sri Lankan children with congenital adrenal hyperplasia, Ceylon Medical Journal, 2017; Jun 30;62(2):112-113.

 

  1. Kariyawasam KWJC, Pathirana RN, Ratnasooriya WD, S Handunnetti, Abeysekera WPKM. Phytochemical profile and in vitro anti-inflammatory activity of aqueous leaf extract of Sri Lankan variety of Psidium guajava Journal of Pharmacognosy and Phytochemistry, 2017; 6(4). 22-26.
  2. Nwokwu DUC, Samarakoon SR, Karunaratne DN, Katuvawila NP, Ediriweera MK, Tennekoon KH. Chitosan Nano-encapsulation Enhances Gedunin Cytotoxicity A gainst Human Non-small-cell Lung Cancer (NCI-H292) Cell Line. Drug Delivery Letters, 2017, 7: 219-226.

 

  1. Gunasekara Peshala, Shiroma Handunnetti, Sunil Premawansa, Elapatha Witharana, Dhanushka Dasanayake, Padmini Ratnayake, Suranjith Seneviratne, Sriyani Dias, Sirimal Premakumara, Rajiva de Silva. IgE cross-reactivity of phospholipase A2 and hyaluronidase of Apis dorsata (Giant Asian honeybee) and Apis mellifera (Western honeybee) venom: Possible use of mellifera venom for diagnosis and immunotherapy of patients allergic to A. dorsata venom. TOXICON, 2017; 137:27-35.

 

  1. Rajkumar Gowri, Jagathpriya Weerasena, Kumudu Fernando.DNA Sequencing and Bioinformatics Analysis of Clone pOr78 from the Species Specific Suppression Subtractive Hybridization Library Constructed from Endemic Wild Rice Species O. rhizomatis. International Journal of Applied Sciences and Biotechnology, 2017; 5(2) 133-140.

 

  1. Rodrigo C, Tennekoon KH, Karunanayake EH, De Silva K, Amarasinghe I, Wijayasiri A. Circulating leptin, soluble leptin receptor, free leptin index, visfatin and selected leptin and leptin receptor gene polymorphisms in sporadic breast cancer. Endocr J. 2017, doi: 10.1507/endocrj.EJ16-0448. [Epub ahead of print].

 

  1. Samarakoon SR, Ediriweera MK, Nwokwu CDU, Bandara CJ, Tennekoon KH, Piyathilaka P, Karunaratne D, Karunaratne V. A Study on Cytotoxic and Apoptotic Potential of a Triterpenoid Saponin (3-O–L-Arabinosyl Oleanolic Acid) Isolated from Schumacheria castaneifolia Vahl in Human Non-Small-Cell Lung Cancer (NCI-H292) Cells. BioMed Research International, 2017 Article ID 9854083, https://doi.org/ 10.1155/2017/9854083.

 

  1. Samarakoon SR, Shanmuganathan C, Ediriweera MK, Piyathilaka P, Tennekoon KH, Thabrew I, Galhena P, De Silva ED. Anti-hepatocarcinogenic and Antioxidant Effects of Mangrove Plant Scyphiphora hydrophyllacea. Pharmacogn Mag. 2017 Jan;13(Suppl 1):S76-S83. doi: 10.4103/0973-1296.203989. Epub 2017 Apr 7.

 

  1. Samaradivakara Saroopa P, Radhika Samarasekera, LM Viranga Tillekeratne, Shiroma M Handunnetti, OVDS Jagathpriya Weerasena, William R Taylor, Qasim Alhadidi, Zahoor A Shah. Bioactivities of n-hexane fraction of Vateria copallifera and GC–MS analysis of its phytoconstituents. Industrial Crops and Products, 2017: 97,87–92.

 

  1. Senathilake KS, Karunanayake EH, Samarakoon SR, Tennekoon KH, de Silva ED, Adhikari A. Oleanolic acid from antifilarial triterpene saponins of Dipterocarpus zeylanicus induces oxidative stress and apoptosis in filarial parasite Setaria digitata in vitro. Exp Parasitol. 2017; 177:13-21. doi:10.1016/j.exppara. 2017.03.007. [Epub ahead of print].

 

  1. Sundralingam T, Tennekoon KH, de Silva S, De Silva S, Hewage AS. Pathogenic and likely pathogenic genetic alterations and polymorphisms in growth hormone gene (GH1) and growth hormone releasing hormone receptor gene (GHRHR) in a cohort of isolated growth hormone deficient (IGHD) children in Sri Lanka. Growth Horm IGF Res. 2017; 36:22-29.

 

  1. Tharmarajah L, Samarakoon SR, Ediriweera MK, Piyathilaka P, Tennekoon KH, Senathilake KS, Rajagopalan U, Galhena PB, Thabrew I. In Vitro Anticancer Effect of Gedunin on Human Teratocarcinomal (NTERA-2) Cancer Stem-Like Cells. Biomed Research International, 2017; 2413197. doi: 10.1155/2017/2413197. Epub 2017 Jun 7.

 

  1. Wickramage I, Tennekoon KH, Ariyaratne MA, Hewage AS, Sundralingam T. CYP2D6 polymorphisms may predict occurrence of adverse effects to tamoxifen: a preliminary retrospective study. Breast Cancer (Dove Med Press). 2017; 9:111-120. doi: 10.2147/BCTT.S126557.

 

  1. Samarakoon SR, Ediriweera MK, Tennekoon KH. A review on ethnopharmacological applications, pharmacological activities and bioactive compounds of Mangifera indica (Mango). Evidence based complementary and alternative medicine. 2017, Article ID 6949835, 24. doi.org/10.1155/2017/6949835.

 

  1. Galhena BP, Samarakoon SR, Thabrew MI, Paul SFD, Perumal V, and Mani C. Protective effect of a polyherbal aqueous extract comprised of Nigella sativa (Seeds), Hemidesmus indicus (Roots), and Smilax glabra (Rhizome) on Bleomycin induced cytogenetic damage in human lymphocytes. Biomed Research International. 2017, Article ID 1856713, 7. doi.org/10.1155/2017/1856713.

 

  1. Nwokw CDU, Samarakoon SR, Karunaratne DN, Katuvawila NP, Pamunuwa GK, Ediriweera MK, Tennekoon KH. Induction of apoptosis in response to improved gedunin by liposomal nano-encapsulation in human non-small-cell lung cancer (NCIH292) cell line. Tropical Journal of Pharmaceutical Research. 2017,16 (9), 20792087.
  1. Ediriweera MK, Samarakoon SR, Tennekoon KH. In vitro assays and techniques utilized in anti-cancer drug discovery. J Applied Toxicology Aug 2018. doi: 10.1002/jat.3658

 

  1. Ediriweera MK, Jayarathna P, Tennekoon KH, Samarakoon SR, Thabrew I, Karunanayake EH, Adhikari A. Campnospermenone A, B and C, three new cytotoxic alkyl-hydroxycyclohexenones from Campnosperma zeylanica Thwaites leaves. Phytochemistry Letters, 2018; 24: 114-119.

 

  1. Narmada Fernando, Rajiva de Silva, Shiroma M Handunnetti, Lilani Karunanayake, Nipun Lakshitha De Silva, H Janaka de Silva, Senaka Rajapakse, Sunil Premawansa. The effect of antimicrobial agents on inflammatory cytokines in acute leptospirosis. Antimicrobial Agents and Chemotherapy. May 2018; 62(5) e02312-17. r62:e02312-17.https://doi .org/10.1128/ AAC.02312-17.

 

  1. Fernando SJA, Faiz NM, Handunnetti SM, De Silva AD, Dasanayake WMDK, Wickremasinghe GD, Karunatilake RMCH, De Silva R. Preliminary study on Chronic granulomatous disease in Sri Lanka. Allergy Asthma & Clinical Immunology. 2018;14: 37. doi: 1186/s13223-018-0264-7.

 

  1. Kumudunayana Gunasekera, Risintha Premaratne, Jagathpriya Weerasena, Sunil Premawansa, Shiroma Handunnetti, Deepika Fernando. Utility of pf/pan RDT for diagnosis in the phase of prevention of re-establishment of malaria in Sri Lanka. Pathogens and Global Health, 2018; 112:360-367. https://doi.org/10.1080/20477724 .2018.1536855.
  2. Karunarathna KHT, Mewan KM, Weerasena OVDSJ, Perera SACN, Edirisinghe ENU, Jayasoma AA. Understanding the genetic relationships and breeding patterns of Sri Lankan tea cultivars with genomic and EST-SSR markers. Scientia Horticulturae. 2018, pp. 72-80.

 

  1. Karunarathna KHT, Mewan KM, Weerasena OVDSJ, Perera SACN, Edirisinghe ENU, Jayasoma AA. EST-SSR Based Insights into Genetic Architecture and Pedigree. Journal of the Korean Tea Society, 2018, 24(3):40~47, https://doi.org/10.29225/2018.24.3.40

 

  1. Nilwala Kottegoda Gayan Kanchana Wijesinghe, Sajeewani Kumarage, Gayani Abayaweera, Sameera R. Samarakoon, Inoka C. Perera, Manjula M. Weerasekera Buddhika Gayani, Ayomi Dilhari. Effect of natural curcuminoids-intercalated layered double hydroxide nanohybrid against Staphylococcus aureus, Pseudomonas aeruginosa, and Enterococcus faecalis: A bactericidal, antibiofilm, and mechanistic study. Microbiology Open. 2018 Sep 17:e00723

 

  1. Liyanaarachchi GVV, KRR Mahanama, HPPS Somasiri, PAN Punyasiri. Development and Validation of a Method for Direct, Underivatized Analysis of Free Amino Acids in Rice using Liquid Chromatography-Tandem Mass  Spectrometry(LC-MS/MS). J of Liquid Chromatography, 2018; 1568: 131-139.

 

  1. Liyanaarachchi GVV, KRR Mahanama, HPPS Somasiri, PAN Punyasiri. Validation of a reverse-phase high-performance liquid chromatography method for the determination of free amino acids in rice using L-Theanine as the internal standard. Food Chemistry, 2018, 240: 196-201.

 

  1. Mapalagamage Maheshi Sasika, Shiroma Mangalika Handunnetti, Gayani Premawansa, Sharmila Thillainathan, Geekiyanage Tharanga Geethapriya Fernando, Karunayokiny Kanapathippillai, Rajitha Wickremeshinghe, Aruna Dharshan de Silva, Sunil Premawansa. Is total serum nitrite and nitrate (NOx) level in dengue patients a potential prognostic marker of dengue haemorrhagic fever? Disease Markers, 2018; Article ID: 5328681, doi.org/10.1155/2018/5328681.

 

  1. Mendis AS, Thabrew MI, Ediriweer MK, Samarakoon SR, Tennekoon KH, Adhikari A, de Silva ED. Isolation of a new sesquiterpene lactone from Vernonia zeylanica (L) Less and its anti-proliferative effects in breast cancer cell lines. Anti-Cancer Agents in Medicinal Chemistry. 2018. Nov 28. doi: 10.2174/1871520619666181128163359

 

  1. Perera HDSM, Samarasekara R, Handunnetti S, Weerasena OVDS, Weeratunga HD, Jabeen A, Chaudhary MI. In vitro pro-inflammatory enzyme inhibition and anti-oxidant potential of selected Sri Lankan medicinal plants. BMC Complementary and Alternative Medicine. 2018; 18: 271.

 

  1. Perera AAU, Weerasena OVDSJ, Dasanayaka PN, Wickramarachchi DC. Development of a rapid, sensitive and specific DNA-based method to detect Ralstonia solanacearumin potato for quarantine purposes. The Journal of National Science Foundation Sri Lanka, 2018; 46 (2), pp. 153 – 158.

 

  1. Rajagopalan Umapriyatharshini, Sameera R Samarakoon, Kamani H Tennekoon, Neelika Malavige, ED de Silva. Screening of five Sri Lankan endemic plants for anti-cancer effects on breast cancer stem cells isolated from MCF-7 and MDA-MB-231 cell lines. Tropical Journal of Pharmaceutical Research. 2018. 17, 9, 1825-1832.

 

  1. Samaradivakara SP, Samarasekera R, Handunnetti SM, Weerasena OVDSJ, Al-Hamashi AA, Slama JT, Taylor WR, Alhadidi Q, Shah ZA, Perera L, Tillekeratne LMV. A bioactive resveratrol trimer from the stem bark of Sri Lankan endemic plant Vateria copallifera. Journal of Natural Products. 2018 Jul 24. doi: 10.1021/acs.jnatprod. 7b00892. [Epub ahead of print].

 

  1. Samarakoon SR, Ediriweera MK, Wijayabandara L, Fernand N, Tharmarajah L, Tennekoon KH, Piyathilaka P, Adhikari A. Isolation of cytotoxic triterpenes from the mangrove plant, Scyphiphora hydrophyllacea CF Gaertn (Rubiaceae). Tropical Journal of Pharmaceutical Research, 2018; 17: 475-481.

 

  1. Sivakumaran N, Samarakoon SR, Adhikari A, Ediriweera MK, Tennekoon KH, Malavige GN, Thabrew MI, and Shrestha RL. Cytotoxic and apoptotic effects of govaniadine isolated from Corydalis govaniana roots on human breast cancer (MCF-7) cells. BioMed Research International, Jul 24; 2018:3171348. doi: 10.1155/2018/3171348. eCollection 2018.

 

  1. Sundralingam T , Tennekoon KH , de Silva S, De Silva S, Hewage S, Ranasinghe R. Novel gross deletion at the GHRHR gene locus possibly mediated by Alu specific microhomology identified in a Sri Lankan patient with isolated growth hormone deficiency. Growth Horm IGF 2018 Oct – Dec; 42-43:94-101. doi: 10.1016/j.ghir.2018.10.005. Epub.
  1. De Silva S, Tennekoon KH, Karunanayake EH. Overview of the genetic basis toward early detection of breast cancer. Breast Cancer: Targets and Therapy, 2019; 11:71-80. Doi:2147/BCTT.S185870.

 

  1. Ediriweera MK, Tennekoon KH, Samarakoon SR. Emerging role of histone deacetylase inhibitors as anti-breast-cancer agents. Drug Discovery Today. 2019; 24(3): 685-702.

 

  1. Ediriweera MK, Tennekoon KH, Samarakoon S In-vitro anti-proliferative assays and techniques used in pre-clinical anti-cancer drug discovery. Frontiers in Anti Cancer Drug Discovery. 2019; 10: 43.

 

  1. Ediriweera MK, Tennekoon KH, Samarakoon SR. Role of the PI3K/AKT/mTOR signaling pathway in ovarian cancer: Biological and therapeutic significance. Seminars in Cancer Biology.2019; 59: 147-160.

 

  1. Ediriweera MK, Tennekoon KH, Samarakoon SR. In vitro assays and techniques utilized in anticancer drug discovery. Journal of Applied Toxicology. 2018; 39(1): 38-7.

 

  1. Gayani B, Dilhari A, Wijesinghe GK, Kumarage S, Abayaweera G, Samarakoon SR, Perera IC, Kottegoda N, Weerasekera MM. Effect of natural curcuminoidsintercalated layered double hydroxide nanohybrid against Staphylococcus aureus, Pseudomonas aeruginosa, and Enterococcus faecalis: A bactericidal, antibiofilm, and mechanistic study. Microbiology Open. 2019; 8(5); 00723.

 

  1. Gunasekara P, Handunnetti SM, Premawansa S, Kaluarachchi P, Karunathilake C, Ratnayake IP, Dias RKS, Premakumara GAS, Dasanayake WMDK, Seneviratne SL, de Silva R.  Diagnosis of Vespa affinis venom allergy: Use of immunochemical methods and a passive basophil activation test. Allergy, Asthma & Clinical Immunology. 2019; 15:80. https://doi.org/10.1186/s13223-019-0394-6.

 

  1. Liyanarachchi V, Mahanama KRR, Somasiri HPPS, Punyasiri PAN. Variations in amino acid profiles inclusing gamma-amino butyric acid (GABA) observed among the most popular rice varieties (Oryza sativa L) consumed in the capital of Sri Lanka. Under review: Journal of the National Science Foundation (2019).

 

  1. Manoharan V, Karunanayake EH, Tennekoon KH, De Silva S, De Silva K, Angunawela P, Lunec J. Nucleotide variants and protein expression of TP53 in a Sri Lankan cohort of patients with head and neck cancer. Molecular Medicine Reports. 2019; 19: 2781-2791. Doi: https://doi.org/10.3892/mmr.2019.9948.

 

  1. Mendis AS, Thabrew I, Ediriweera MK, Samarakoon SR, Tennekoon KH, Adhikari A, de Silva ED. Isolation of a new sesquiterpene lactone from Vernonia zeylanica (L) Less and its anti-proliferative effects in breast cancer cell lines. Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry-Anti-Cancer Agents). 2019; 19(3): 410-424.

 

  1. Senarath U, Senanayake S, Pathirana S, Karunaweera N, Weerasinghe M.C, Gunawardena N.S, Munugoda I.P, Jayasinghe S, Amarathunga P, Corea E. and De Silva V. Health in Rural Sri Lanka: a cross-sectional survey of 3 rural districts. Ceylon Medical Journal. 2019; 64(3): 103-110. DOI:http://doi.org/10.4038/cmj.v64i3.8957.

 

  1. Sigera PC, Amarasekara R, Rodrigo C, Rajapakse S, Weerathunga P, De Silva NL, Chun Huang H, Saho MK, Benjamin A. Pinsky, Dylan R. Pillai, Hasitha A. Tissera, Jayasinghe S, Handunnetti SM, Fernando D. Risk prediction for severe disease in early dengue infection; the Colombo Dengue Study. BMC Infectious Diseases. 2019; 19: 680.

 

  1. Tennekoon KH, Abeysinghe NK, Thabrew I, Samarakoon SR, Ediriweera MK, Pathiranage VPC, Mendis AS. Vernolactone Promotes Apoptosis and Autophagy in Human Teratocarcinomal (NTERA-2) – Cancer Stem- Like Cells. Stem Cell International. 2019; 1-
  1. Chandrakanthan M, Handunnetti SM, Premakumara GSA, and Kathirgamanathar S. Topical Anti-Inflammatory Activity of Essential Oils of Alpinia calcarata, Its Main Constituents, and Possible Mechanism of Action, Evidence-Based Complementary and Alternative Medicine, 2020, Article ID 2035671, 19 pages https://doi.org/10.1155/2020/2035671.

 

  1. Darshani T, Fronczek FR, Priyadarshani VV, Samarakoon SR, Perera IC, Perera T. Synthesis and characterization of novel naphthalene-derivatized tridentate ligands and their net neutral rhenium tricarbonyl complexes and cytotoxic effects on non-small cell lung cancer cells of interest. Polyhedron, 2020, 187: 114652.

 

  1. Fernando Y, Wickremeshinghe P, De Silva U, Alahakoon M, Anuradha KWDA and Handunnetti S. Differences in serum markers of oxidative stress in well controlled and poorly controlled asthma in Sri Lankan children: a pilot study, Allergy Asthma & Clinical Immunology 2020 16:66 https://doi.org/10.1186/s13223-020-00463-9.

 

  1. Jayasuriya WJABN, Handunnetti SM, Wanigatunge CA, Fernando GH, Abeytunga DTU, Suresh TS. Anti-Inflammatory Activity of Pleurotus ostreatus, a Culinary Medicinal Mushroom, in Wistar Rats. Evidence-Based Complementary and Alternative Medicine Volume 2020, Article ID 6845383, 9 pages https://doi.org/10.1155/2020/6845383.

 

  1. Kariyawasam KWJC, Sirisena PDNN, Nanayakkara HLC, Ratnasooriya WD, Handunnetti SM. Vitex negundo leaf extract inhibits IL-6 and TNF-α secretion and phagocytosis in human leukocytes, Journal of Herbal Medicine 2020, doi:https://doi.org/10.1016/ j.hermed. 2020.100341.

 

  1. Karunarathna KHT, Senathilake NHKS, Mewan KM, Weerasena OVDSJ, Perera SACN. In silico structural homology modelling of EST073 motif coding protein of tea Camellia sinensis (L). Journal of Genetic Engineering and Biotechnology. 2020, 18: DOI:1186/s43141-020-00038-6.

 

  1. Kotelawala J T, Ranasinghe R, Rodrigo C, Tennekoon KH, Silva K. Evaluation of non-coding region sequence variants and mitochondrial haplogroups as potential biomarkers of sporadic breast cancer in individuals of Sri Lankan Sinhalese ethnicity. Biomedical Reports. 2020, 12(6):339-347.

 

  1. Kothalawala SD, Edward D, Harasgama JC, Ranaweera L, Weerasena OVDSJ, Niloofa R, Ratnasooriya WD, Premakumara GAS,Handunnetti SM. Immunomodulatory activity of traditional Sri Lankan concoction of  Coriandrum sativuma and Coscinium fenestratum G. Evidence-Based Complementray and Alternatuive Medicine, 2020 Article ID 9715060, 10 pages https://doi.org/10.1155/ 2020/9715060.

 

  1. Liyanaarachchi GVV, Mahanama KRR, Somasiri HPPS, Punyasiri PAN, Kottawa-Arachchi JD. Analysis of Total Amino Acids in Rice Using a Validated Reversed-Phase High Performance Liquid Chromatographic Method with Diode detection. International Journal of Analytical and Bioanalytical Methods, 2020, 2.008, 1-12 DOI: 10.35840/ijabm/2407.

 

  1. Liyanaarachchi GVV, Mahanama KRR, Somasiri HPPS, Punyasiri PAN, Kottawa-Arachchi JD. Total and free amino acid contents of popular rice varieties (Oryza sativa) consumed in the capital city of Sri Lanka, 2020, Journal of National Science Foundation, Sri Lanka (in press).

 

  1. Mahendran R, Pathirana S, Piyatilake ITS, Perera SSN, Weerasinghe MC (2020) Assessment of environmental variability on malaria transmission in a malaria-endemic rural dry zone locality of Sri Lanka: The wavelet approach. PLoS ONE 15(2): e0228540. https://doi.org/10.1371/ journal.pone.0228540.

 

  1. Manoharan V, Karunanayake EH, Tennekoon KH, De Silva S, Imthikab AIA, De Silva K, Angunawela P, Vishwakula S, Lunec J. Pattern of nucleotide variants of TP53 and their correlation with the expression of p53 and its downstream proteins in a Sri Lankan cohort of breast and colorectal cancer patients. BMC Cancer. 2020 20:72.

 

  1. Mapalagamage M, Handunnetti SM, Ananda Rajitha Wickremasinghe, Gayani Premawansa, Sharmila Thillainathan, Tharanga Fernando, Karunayokiny Kanapathippillai, Aruna Dharshan De Silva, Sunil Premawansa. High levels of serum Angiopoietin 2 and Angiopoietin 2/1 ratio at critical stage of dengue hemorrhagic fever patients and their association with clinical and biochemical parameters. Journal of Clinical Microbiology, 2020, 58:e00436-19. https://doi.org/10 .1128/JCM.00436-19.

 

  1. Pathiranage VC, Lowe J N, Jajagopalan U, Ediriweera MK, Senathilake K, Piyathilake P, Tennekoon KH, Samarakoon SRS. Hexane Extract of Garcinia quaesitaFruits Induces Apoptosis in Breast Cancer Stem Cells Isolated from Triple Negative Breast Cancer Cell Line MDA-MB-231. Nutrition and Cancer; 2020, June 1-11.

 

  1. Pathiranage VC, Thabrew I, Samarakoon SRS, Tennekoon KH, Rajagopalan U, Ediriweera MK. Evaluation of anticancer effects of a pharmaceutically viable extract of a traditional polyherbal mixture against non-small-cell lung cancer cells. Journal of Integrative Medicine. 2020, 18:242-252.

 

  1. Rajapakse S, Weeratunga PN, Balaji K, Ramchandani KC, de Silva US, Ranasinghe SA, Gunarathne D, Wijerathne PPB, Fernando N, Handunnetti SM, Fernando SD. Seroprevalence of leptospirosis in an endemic mixed urban and semi-urban setting – A community-based study in the district of Colombo, Sri Lanka. PLoS Neglected Tropical Diseases, 2020, 14(5): e0008309. https://doi.org/10.1371/journal. pntd.0008309.

 

 

  1. Ranasinghe HN, Fernando N, Handunnetti S, Weeratunga PN, Katulanda P, Rajapakse S, Galappatthy P, Constantine G R. The impact of propranolol on nitric oxide and total antioxidant capacity in patients with resistant hypertension—evidence from the APPROPRIATE trial, BMC Research Notes; 2020, 13:228 https://doi.org/ 10.1186/s13104-020-05067-5.

 

  1. Samanthi KAU, Welideniya DT, Acharige AD, Samarakoon SR, Rathnayaka RK, de Silva M, Perera SS, Pieris C, Wanninayake UK, Jayathilaka A, Karunaratne V, Amaratunga GAJ, Gunasekera DS. An efficient and high-yielding method for extraction and purification of linamarin from Cassava; in vitrobiological evaluation. Natural Products Research, https://doi.org/10.1080/14786419. 2020.1744136.

 

  1. Santhirasegaram S, Wickramarachchi SR, Attanayake RN, Weerakoon G, Samarakoon S, Wijeratne K, Paranagama PA. A novel cytotoxic compound from the endolichenic fungus, Xylaria psidiiinhabiting the lichen, Amandinea medusulina. Natural Product Communications, 2020, 15(7): 1–8.

 

  1. Senanayake KS, Söderberg J, Põlajev A, Malmberg M, Karunanayake EH, Tennekoon KH, Samarakoon SR, Bongcam-Rudloff E, Niazi A. The Genome of Setaria digitata: A Cattle Nematode Closely Related to Human Filarial Parasites. Genome Biology and Evolution. 2020, 12:3971-3976.

 

  1. Threeswaran R, De Silva NL, Arya R, Gooneratne L, Handunnetti SM, Rajapakse S. Haemostatic derangement in leptospirosis: a preliminary prospective comparative study. International Journal of Critical Illness and Injury Science, 10: 28-32.

 

  1. Withana WVE, Kularathna RMRE, Kottearachchi NS, Kekulandara DS, Weerasena J, Steele KA. In silico analysis of the fragrance gene (badh2) in Asian rice (Oryza sativaL.) germplasm and validation of allele specific markers. Plant Genetic Resources: Characterization and Utilization, 2020 1–10,doi:10.1017/S1479262120000015.

 

Preprints

  1. Senathilake K, Samarakoon S, Tennekoon K. Virtual screening of inhibitors against spike glycoprotein of SARS-CoV-2: a drug repurposing approach, 2020.