P. D. Gangani

About

I graduated in 2016 with a Bachelor of Science (Honors) degree specializing in Immunology and Integrative Molecular Biology from department of Zoology and Environmental Sciences from the Faculty of Science, University of Colombo. During my undergraduate studies, I conducted a research titled “Identifying the spatial genetic structure of Aedes aegypti mosquitoes in dengue-endemic areas in Sri Lanka Using microsatellite markers under supervision of Dr Gayani Galhena. Currently, I am reading for a PhD at the Institute of Biochemistry, Molecular Biology, and Biotechnology (IBMBB), University of Colombo on a research project funded by International Center for Genetic Engineering and Biotechnology (ICGEB), Trieste, Italy awarded to my primary supervisor.  During my PhD study, I have studied and compared the immune response in terms of IgM/IgG antibody levels in rat sera raised against the pathogenic forms, Leptospira interrogans and non-pathogenic L. biflexa. Currently I am working with several immunoassays using monoclonal antibodies produced using hybridoma technology, targeting the development of immunodiagnostic assays for early detection of leptospirosis.

Publications and Communications

Publications in peer-reviewed indexed Journals

·       Gangani D, Dissanayake W, de Silva R, Anuradha K, Karunanayake L, Fernando N, Rajapakse S, Premawansa S, Handunnnetti S. Humoral immune response and changes in peritoneal cell populations in rats immunized against two Leptospira serovars; serovar patoc and serovar pyrogenes. BMC Immunology 24, 39 (2023). https://doi.org/10.1186/s12865-023-00574

Research communications

1.    Gangani PD, Ishaka GKD, Fernando N, Karunanayake L, Rajapakse S, Premawansa S, Handunnetti SM. (2019) Comparison of IgG and IgM responses in rats immunized with two types of antigen preparations of Leptospira biflexa serovar Patoc. Proceedings of the 11^th Annual Scientific Sessions, IBMBB, University of Colombo, Sri Lanka; 22.

2.      P D Gangani, W G K Anuradha, N Fernando, M G Tammitiyagodage, L Karunanayake, S Rajapakse, S Premawansa, S M Handunnetti. (2021) Identification of immunogens of L. biflexa serovar Patoc. Proceedings of the 9th Biennial Scientific Sessions of Allergy and Immunology Society of Sri Lanka; 17.

3.    WGK Anuradha, PD Gangani, L Karunanayake, N Fernando, SM Handunnetti. (2021) Comparison of antigen profiles of pathogenic serovars of L. interrogans and non-pathogenic L. biflexa. Proceedings of the 9th Biennial Scientific Sessions of Allergy and Immunology Society of Sri Lanka; 27.

4.      Gangani PD, Anuradha WGK , Fernando N , Karunanayake L, Rajapakse S, Premawansa S, Handunnetti SM.(2022) Comparison of rat immune responses to two pathogenic Leptospira serovars prevalent in Sri Lanka. Proceedings of third International Conference on Frontiers in Molecular Life Science Organized by IBMBB, University of Colombo, Sri Lanka on 06th & 07th April 2022: 59.

5.     Anuradha WGK, Gangani PD, Fernando N, Karunanayake L, Tammitiyagodage MG, Handunnetti SM. (2022) Comparison of immunoreactive proteins profile of pathogenic and non-pathogenic serovars of Leptospira. Proceedings of third International Conference on Frontiers in Molecular Life Science Organized by IBMBB, University of Colombo, Sri Lanka on 06th & 07th April 2022: 37.

6.    PD Gangani, W Dissanayake, R de Silva, WGK Anuradha , L Karunanayake ,N Fernando, S Rajapakse , S Premawansa , S Handunnetti (2024). Humoral immune response and associated changes in peritoneal lymphocyte populations in rats immunized against two Leptospira serovars. Proceedings of the 10th Biennial Scientific Sessions of Allergy and Immunology Society of Sri Lanka;24.